SEC
|
Mehra Anand
|
N/A
|
|
+667K
|
$2.25
|
+$1.50M
|
|
SEC
|
Leonard Braden Michael
|
N/A
|
|
+374K
|
$1.27
|
+$474.43K
|
|
SEC
|
Leonard Braden Michael
|
N/A
|
|
+274K
|
$1.31
|
+$358.59K
|
|
SEC
|
Leonard Braden Michael
|
N/A
|
|
+155K
|
$1.30
|
+$201.14K
|
|
SEC
|
Leonard Braden Michael
|
N/A
|
|
+352K
|
$1.15
|
+$405.26K
|
|
SEC
|
Leonard Braden Michael
|
N/A
|
|
+1.5M
|
$1.13
|
+$1.74M
|
|
SEC
|
Leonard Braden Michael
|
N/A
|
|
+545K
|
$1.15
|
+$626.75K
|
|
SEC
|
Leonard Braden Michael
|
N/A
|
|
+1.6M
|
$1.11
|
+$1.79M
|
|
SEC
|
Powell Andrew Kenneth William
|
N/A
|
|
+15K
|
$1.24
|
+$17.98K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-6K
|
$5.08
|
-$30.48K
|
|
SEC
|
Balthaser Kevin
|
Chief Financial Officer
|
|
+9.5K
|
$7.90
|
+$74.97K
|
|
SEC
|
Loerop James
|
Chief Business Officer
|
|
+15K
|
$6.80
|
+$99.99K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-6K
|
$7.32
|
-$43.92K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-6K
|
$10.28
|
-$61.68K
|
|
SEC
|
Manion Douglas J.
|
Pres and CEO
|
|
+6.3K
|
$7.86
|
+$49.52K
|
|
SEC
|
Manion Douglas J.
|
Pres and CEO
|
|
+6.5K
|
$7.74
|
+$50.31K
|
|
SEC
|
Balthaser Kevin
|
Chief Financial Officer
|
|
-1.9K
|
$12.45
|
-$23.58K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-31K
|
$12.51
|
-$385.77K
|
|
SEC
|
Walker Neal
|
N/A
|
|
-59K
|
$12.50
|
-$740.50K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-5K
|
$13.06
|
-$65.30K
|
|
SEC
|
Loerop James
|
Chief Business Officer
|
|
-4.3K
|
$13.89
|
-$59.27K
|
|
SEC
|
Walker Neal
|
N/A
|
|
-30K
|
$16.66
|
-$499.80K
|
|
SEC
|
Walker Neal
|
N/A
|
|
-40K
|
$15.11
|
-$604.40K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-5K
|
$15.88
|
-$79.40K
|
|
SEC
|
SCHIFF ANDREW N
|
N/A
|
|
-7.3K
|
$16.16
|
-$118.36K
|
|
SEC
|
SCHIFF ANDREW N
|
N/A
|
|
-46K
|
$16.45
|
-$749.12K
|
|
SEC
|
SCHIFF ANDREW N
|
N/A
|
|
-20K
|
$15.14
|
-$296.21K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
-70K
|
$15.15
|
-$1.06M
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-30K
|
$16.28
|
-$488.40K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
-56K
|
$15.91
|
-$895.78K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-27K
|
$15.71
|
-$426.76K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
-13K
|
$15.55
|
-$199.40K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
-383
|
$12.68
|
-$4.86K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
-1.4K
|
$12.66
|
-$17.57K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
-3.6K
|
$12.66
|
-$45.51K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
+1.3K
|
$17.22
|
+$22.25K
|
|
SEC
|
Gordon David N.
|
Chief Medical Officer
|
|
-2.6K
|
$16.98
|
-$44.67K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
-9.5K
|
$21.96
|
-$208.44K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
-12K
|
$22.10
|
-$263.65K
|
|
SEC
|
Gordon David N.
|
Chief Medical Officer
|
|
+36K
|
$22.01
|
+$783.25K
|
|
SEC
|
Monahan Joseph
|
Chief Scientific Officer
|
|
+28K
|
$21.64
|
+$610.46K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+18K
|
$21.64
|
+$392.81K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+40K
|
$21.64
|
+$860.30K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
-87K
|
$26.45
|
-$2.31M
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
-30K
|
$26.84
|
-$805.20K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+17K
|
$23.83
|
+$404.44K
|
|
SEC
|
Gordon David N.
|
Chief Medical Officer
|
|
+21K
|
$23.83
|
+$499.41K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+24K
|
$23.83
|
+$568.82K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+67K
|
$23.92
|
+$1.59M
|
|
SEC
|
Mehra Anand
|
N/A
|
|
+15K
|
$18.34
|
+$268.35K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+2.6K
|
$21.35
|
+$54.59K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+2.6K
|
$21.35
|
+$54.81K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+7.5K
|
$21.35
|
+$159.78K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+1.2K
|
$4.59
|
+$5.67K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+930
|
$4.59
|
+$4.27K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+2.2K
|
$4.59
|
+$9.93K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+59K
|
$2.33
|
+$137.98K
|
|
SEC
|
Gordon David N.
|
Chief Medical Officer
|
|
+4.6K
|
$1.50
|
+$6.96K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+24K
|
$1.32
|
+$31.22K
|
|
SEC
|
Gordon David N.
|
Chief Medical Officer
|
|
+63K
|
$1.32
|
+$83.76K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+24K
|
$1.32
|
+$31.33K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+52K
|
$1.32
|
+$68.69K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+12K
|
$1.26
|
+$15.62K
|
|
SEC
|
Gordon David N.
|
Chief Medical Officer
|
|
+15K
|
$1.26
|
+$19.01K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+19K
|
$1.26
|
+$23.42K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+106K
|
$1.26
|
+$133.55K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+2.6K
|
$1.28
|
+$3.27K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+2.6K
|
$1.28
|
+$3.29K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+7.1K
|
$1.28
|
+$9.12K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+798
|
$1.81
|
+$1.44K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+894
|
$1.81
|
+$1.62K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+2.2K
|
$1.81
|
+$3.95K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+1.2K
|
$1.80
|
+$2.22K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+930
|
$1.80
|
+$1.67K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+2.3K
|
$1.80
|
+$4.05K
|
|
SEC
|
Gordon David N.
|
Chief Medical Officer
|
|
+4.4K
|
$2.34
|
+$10.18K
|
|
SEC
|
DEERFIELD PARTNERS, L.P.
|
N/A
|
|
-699K
|
$2.69
|
-$1.88M
|
|
SEC
|
DEERFIELD PARTNERS, L.P.
|
N/A
|
|
-1.7K
|
$4.50
|
-$7.67K
|
|
SEC
|
DEERFIELD PARTNERS, L.P.
|
N/A
|
|
-454K
|
$4.59
|
-$2.09M
|
|
SEC
|
DEERFIELD PARTNERS, L.P.
|
N/A
|
|
-615K
|
$6.13
|
-$3.77M
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+2.6K
|
$6.96
|
+$17.87K
|
|
SEC
|
Fair Brett
|
Chief Commercial Officer
|
|
+2.6K
|
$6.96
|
+$17.87K
|
|
SEC
|
Powala Christopher
|
Chief Reg & Develop Officer
|
|
+2.3K
|
$6.96
|
+$15.91K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+2.6K
|
$6.96
|
+$17.87K
|
|
SEC
|
Shanler Stuart
|
Chief Scientific Officer
|
|
+2.6K
|
$6.96
|
+$17.87K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+7.2K
|
$6.96
|
+$50.26K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+769
|
$6.30
|
+$4.84K
|
|
SEC
|
Fair Brett
|
Chief Commercial Officer
|
|
+1.3K
|
$6.30
|
+$7.89K
|
|
SEC
|
Powala Christopher
|
Chief Reg & Develop Officer
|
|
+1.2K
|
$6.30
|
+$7.43K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+894
|
$6.30
|
+$5.63K
|
|
SEC
|
Shanler Stuart
|
Chief Scientific Officer
|
|
+1K
|
$6.30
|
+$6.54K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+2.1K
|
$6.30
|
+$13.18K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+1.2K
|
$7.31
|
+$9.06K
|
|
SEC
|
Fair Brett
|
Chief Commercial Officer
|
|
+725
|
$7.31
|
+$5.30K
|
|
SEC
|
Powala Christopher
|
Chief Reg & Develop Officer
|
|
+943
|
$7.31
|
+$6.89K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+930
|
$7.31
|
+$6.80K
|
|
SEC
|
Shanler Stuart
|
Chief Scientific Officer
|
|
+930
|
$7.31
|
+$6.80K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+2.2K
|
$7.31
|
+$15.86K
|
|
SEC
|
Mehra Anand
|
N/A
|
|
+372K
|
$10.75
|
+$4.00M
|
|
SEC
|
Tullman Stephen A.
|
N/A
|
|
+7.1K
|
$14.00
|
+$99.40K
|
|
SEC
|
Tullman Stephen A.
|
N/A
|
|
+6.6K
|
$15.00
|
+$99.00K
|
|
SEC
|
Tullman Stephen A.
|
N/A
|
|
+6.3K
|
$15.97
|
+$99.81K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
-5K
|
$20.00
|
-$100.00K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
-10K
|
$20.00
|
-$200.00K
|
|
SEC
|
Powell Andrew Kenneth William
|
N/A
|
|
+500
|
$19.12
|
+$9.56K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+5K
|
$18.10
|
+$89.76K
|
|
SEC
|
Fair Brett
|
Chief Commercial Officer
|
|
+2.9K
|
$18.10
|
+$52.44K
|
|
SEC
|
Powala Christopher
|
Chief Reg & Develop Officer
|
|
+3.7K
|
$18.10
|
+$67.33K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+5K
|
$18.22
|
+$90.55K
|
|
SEC
|
Shanler Stuart
|
Chief Scientific Officer
|
|
+3.7K
|
$18.10
|
+$67.33K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+8.7K
|
$18.10
|
+$157.07K
|
|
SEC
|
Molineaux Christopher P.
|
N/A
|
|
+2.3K
|
$16.52
|
+$38.00K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+1.3K
|
$16.59
|
+$20.74K
|
|
SEC
|
Tullman Stephen A.
|
N/A
|
|
+27K
|
$16.54
|
+$441.62K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+10K
|
$16.75
|
+$167.50K
|
|
SEC
|
Molineaux Christopher P.
|
N/A
|
|
+2.4K
|
$0.55
|
+$1.31K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
+2K
|
$24.19
|
+$47.27K
|
|
SEC
|
Powala Christopher
|
Chief Operating Officer
|
|
+2K
|
$24.17
|
+$49.21K
|
|
SEC
|
Ruffo Frank
|
Chief Financial Officer
|
|
+1.8K
|
$24.18
|
+$42.92K
|
|
SEC
|
Shanler Stuart
|
Chief Scientific Officer
|
|
+1.9K
|
$24.17
|
+$46.26K
|
|
SEC
|
Walker Neal
|
President and CEO
|
|
+4.1K
|
$24.18
|
+$100.27K
|
|
SEC
|
SCHIFF ANDREW N
|
N/A
|
|
+109K
|
$23.02
|
+$2.50M
|
|
SEC
|
Molineaux Christopher P.
|
N/A
|
|
+7.6K
|
$0.51
|
+$3.88K
|
|
SEC
|
Vivo Ventures VII Affiliates Fund, L.P.
|
N/A
|
|
-425K
|
$30.82
|
-$13.10M
|
|
SEC
|
Mehra Anand
|
N/A
|
|
-750K
|
$28.25
|
-$21.19M
|
|
SEC
|
Vivo Ventures VII Affiliates Fund, L.P.
|
N/A
|
|
-908K
|
$23.03
|
-$20.91M
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
-3.9K
|
$21.83
|
-$85.40K
|
|
SEC
|
FMR LLC
|
N/A
|
|
-3.8K
|
$21.94
|
-$82.28K
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
-1.8K
|
$24.66
|
-$45.40K
|
|
SEC
|
RA Capital Healthcare Fund LP
|
N/A
|
|
-526K
|
$24.19
|
-$12.71M
|
|
SEC
|
Ali-Jackson Kamil
|
Chief Legal Officer
|
|
-3.7K
|
$20.35
|
-$76.07K
|
|
SEC
|
RA Capital Healthcare Fund LP
|
N/A
|
|
+40K
|
$17.15
|
+$681.30K
|
|
SEC
|
RA Capital Healthcare Fund LP
|
N/A
|
|
+7.8K
|
$19.87
|
+$155.05K
|
|
SEC
|
RA Capital Healthcare Fund LP
|
N/A
|
|
+16K
|
$19.10
|
+$298.67K
|
|
SEC
|
RA Capital Healthcare Fund LP
|
N/A
|
|
+244K
|
$14.00
|
+$3.42M
|
|
SEC
|
RA Capital Healthcare Fund LP
|
N/A
|
|
+5.4K
|
$14.03
|
+$75.90K
|
|
SEC
|
Kolchinsky Peter
|
N/A
|
|
+35K
|
$14.89
|
+$521.14K
|
|
SEC
|
Kolchinsky Peter
|
N/A
|
|
+43K
|
$14.06
|
+$601.95K
|
|
SEC
|
CHA ALBERT
|
N/A
|
|
+455K
|
$11.00
|
+$5.00M
|
|
SEC
|
FMR LLC
|
N/A
|
|
+335K
|
$11.00
|
+$3.69M
|
|
SEC
|
Mehra Anand
|
N/A
|
|
+409K
|
$11.00
|
+$4.50M
|
|
SEC
|
POWELL MICHAEL
|
N/A
|
|
+409K
|
$11.00
|
+$4.50M
|
|
SEC
|
Vivo Ventures VII Affiliates Fund, L.P.
|
N/A
|
|
+455K
|
$11.00
|
+$5.00M
|
|
SEC
|
Kolchinsky Peter
|
N/A
|
|
+2.2M
|
$10.86
|
+$24.30M
|
|
SEC
|
CHA ALBERT
|
N/A
|
|
+13K
|
$11.00
|
+$146.87K
|
|
SEC
|
Vivo Ventures VII Affiliates Fund, L.P.
|
N/A
|
|
+13K
|
$11.00
|
+$146.87K
|
|