|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-36K
|
$16.16
|
-$583.86K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$15.64
|
-$156.40K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-4.2K
|
$15.82
|
-$66.25K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-3.8K
|
$14.03
|
-$53.97K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-2.6K
|
$14.33
|
-$37.57K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-6.3K
|
$14.33
|
-$90.71K
|
|
|
SEC
|
Vairavan Latha
|
SVP Chief Financial Officer
|
|
-89
|
$14.33
|
-$1.28K
|
|
|
SEC
|
Watanabe Todd
|
See Remarks
|
|
-12K
|
$14.33
|
-$165.47K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$14.30
|
-$143.00K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-29K
|
$15.05
|
-$432.69K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-9.2K
|
$13.84
|
-$127.44K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$13.37
|
-$135.56K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+2.6K
|
$13.08
|
+$34.61K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+2.3K
|
$13.34
|
+$30.26K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-1.8K
|
$13.78
|
-$24.80K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+5K
|
$13.66
|
+$68.85K
|
|
|
SEC
|
Edwards Larry Todd
|
See Remarks
|
|
-7.5K
|
$14.07
|
-$104.84K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+2.5K
|
$13.62
|
+$34.32K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+8.7K
|
$13.76
|
+$119.35K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+6.3K
|
$13.60
|
+$85.68K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-3.9K
|
$13.59
|
-$52.61K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-2.6K
|
$15.19
|
-$39.45K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-5K
|
$15.20
|
-$76.46K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-11K
|
$15.19
|
-$173.90K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$14.64
|
-$146.40K
|
|
|
SEC
|
Topper David Joseph
|
Chief Financial Officer
|
|
-9.6K
|
$15.80
|
-$151.68K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$15.12
|
-$151.20K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-3.7K
|
$17.55
|
-$64.43K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-1.2K
|
$17.61
|
-$21.13K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-61K
|
$14.99
|
-$920.43K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-3.8K
|
$13.10
|
-$49.43K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-25K
|
$13.07
|
-$326.95K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-3.3K
|
$13.03
|
-$42.52K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$13.00
|
-$130.00K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-12K
|
$12.70
|
-$153.87K
|
|
|
SEC
|
Edwards Larry Todd
|
See Remarks
|
|
-2.2K
|
$12.70
|
-$27.60K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-8.3K
|
$12.70
|
-$105.89K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-19K
|
$12.70
|
-$245.12K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$12.71
|
-$127.10K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$14.67
|
-$146.70K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-1.7K
|
$14.00
|
-$23.67K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-15K
|
$15.17
|
-$227.55K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$12.51
|
-$125.10K
|
|
|
SEC
|
Edwards Larry Todd
|
See Remarks
|
|
+1.1K
|
$7.11
|
+$7.77K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
+5.7K
|
$3.28
|
+$18.55K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
+6K
|
$3.52
|
+$21.25K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-16K
|
$10.14
|
-$162.47K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-1.8K
|
$9.68
|
-$17.18K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-69K
|
$10.29
|
-$712.34K
|
|
|
SEC
|
Curran Terrie
|
N/A
|
|
-8.7K
|
$10.85
|
-$94.25K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-15K
|
$8.68
|
-$134.03K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-5K
|
$8.68
|
-$43.53K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-14K
|
$8.68
|
-$120.40K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$8.65
|
-$86.50K
|
|
|
SEC
|
Edwards Larry Todd
|
SVP Chief Commercial Officer
|
|
-3.7K
|
$10.01
|
-$37.29K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$9.26
|
-$92.60K
|
|
|
SEC
|
Topper David Joseph
|
Chief Financial Officer
|
|
-12K
|
$9.48
|
-$110.21K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$10.77
|
-$107.70K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-1.7K
|
$8.29
|
-$14.33K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-13K
|
$9.02
|
-$119.12K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-5.2K
|
$9.02
|
-$47.08K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-14K
|
$9.02
|
-$130.67K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$9.87
|
-$98.70K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$9.31
|
-$93.10K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-10K
|
$8.01
|
-$80.10K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-73K
|
$8.73
|
-$636.87K
|
|
|
SEC
|
Matsuda Masaru
|
See Remark
|
|
-1.8K
|
$9.01
|
-$15.99K
|
|
|
SEC
|
Edwards Larry Todd
|
SVP Chief Commercial Officer
|
|
-7.6K
|
$8.98
|
-$68.61K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-9.6K
|
$8.74
|
-$83.51K
|
|
|
SEC
|
Matsuda Masaru
|
See Remark
|
|
-5K
|
$8.74
|
-$43.84K
|
|
|
SEC
|
Moore Matthew Richard
|
SVP and Chief Business Officer
|
|
-4.7K
|
$8.74
|
-$40.91K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-14K
|
$8.74
|
-$120.46K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-4.8K
|
$11.12
|
-$53.18K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+21K
|
$9.50
|
+$199.99K
|
|
|
SEC
|
Matsuda Masaru
|
See Remark
|
|
-3.8K
|
$11.12
|
-$41.81K
|
|
|
SEC
|
Moore Matthew Richard
|
SVP and Chief Business Officer
|
|
-3.5K
|
$11.12
|
-$38.56K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-15K
|
$11.12
|
-$165.72K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-2.5K
|
$10.60
|
-$26.13K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-1.3K
|
$3.54
|
-$4.69K
|
|
|
SEC
|
Matsuda Masaru
|
See Remark
|
|
-1.9K
|
$1.98
|
-$3.66K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+80K
|
$2.50
|
+$200.00K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-1.6K
|
$7.04
|
-$11.30K
|
|
|
SEC
|
Matsuda Masaru
|
See Remark
|
|
-1.8K
|
$7.80
|
-$14.27K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
+1.5K
|
$6.38
|
+$9.33K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-8.5K
|
$13.97
|
-$118.75K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-8.5K
|
$12.01
|
-$102.09K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-851
|
$15.26
|
-$12.99K
|
|
|
SEC
|
Burrows Scott L
|
Chief Financial Officer
|
|
-291
|
$15.26
|
-$4.44K
|
|
|
SEC
|
Lock Kenneth A.
|
Chief Commercial Officer
|
|
-831
|
$15.26
|
-$12.68K
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
-690
|
$15.26
|
-$10.53K
|
|
|
SEC
|
Turney Patricia A.
|
SVP, Operations
|
|
-831
|
$15.26
|
-$12.68K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-2.4K
|
$15.26
|
-$37.16K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-1.8K
|
$15.83
|
-$27.72K
|
|
|
SEC
|
Burrows Scott L
|
Chief Financial Officer
|
|
-1.9K
|
$15.90
|
-$29.42K
|
|
|
SEC
|
Lock Kenneth A.
|
Chief Commercial Officer
|
|
-2.4K
|
$15.96
|
-$37.79K
|
|
|
SEC
|
Matsuda Masaru
|
See Remarks
|
|
-1.4K
|
$15.83
|
-$22.70K
|
|
|
SEC
|
Moore Matthew Richard
|
See Remarks
|
|
-1.6K
|
$15.83
|
-$25.49K
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
-2K
|
$15.96
|
-$32.00K
|
|
|
SEC
|
Turney Patricia A.
|
SVP, Operations
|
|
-2.4K
|
$15.96
|
-$37.79K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-7.8K
|
$15.93
|
-$124.49K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-8.5K
|
$16.98
|
-$144.33K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-1K
|
$17.01
|
-$17.01K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-1K
|
$17.00
|
-$17.00K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
-1.5K
|
$15.01
|
-$22.14K
|
|
|
SEC
|
Watanabe Todd Franklin
|
See Remarks
|
|
-1K
|
$17.06
|
-$17.06K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-1K
|
$19.51
|
-$19.51K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-6K
|
$20.29
|
-$121.74K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-270K
|
$0.08
|
-$21.60K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-6K
|
$24.80
|
-$148.80K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+250K
|
$20.00
|
+$5.00M
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-6K
|
$24.40
|
-$146.40K
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
-2.2K
|
$25.41
|
-$55.83K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-6.4K
|
$17.21
|
-$110.37K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-1K
|
$22.07
|
-$22.07K
|
|
|
SEC
|
OrbiMed Capital GP VII LLC
|
N/A
|
|
-342K
|
$21.31
|
-$7.29M
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-1K
|
$21.06
|
-$21.06K
|
|
|
SEC
|
Matsuda Masaru
|
SVP and General Counsel
|
|
+3.1K
|
$5.31
|
+$16.35K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-1K
|
$21.76
|
-$21.76K
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
-2.2K
|
$20.42
|
-$44.86K
|
|
|
SEC
|
OrbiMed Capital GP VII LLC
|
N/A
|
|
-878K
|
$20.68
|
-$18.16M
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-1K
|
$21.43
|
-$21.43K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-300
|
$17.00
|
-$5.10K
|
|
|
SEC
|
Burnett Patrick
|
See Remarks
|
|
+17K
|
$0.91
|
+$15.28K
|
|
|
SEC
|
Burrows Scott L
|
Chief Financial Officer
|
|
+13K
|
$0.38
|
+$4.94K
|
|
|
SEC
|
Lock Kenneth A.
|
Chief Commercial Officer
|
|
+12K
|
$1.20
|
+$14.73K
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
+12K
|
$1.02
|
+$12.69K
|
|
|
SEC
|
Turney Patricia A.
|
SVP, Operations
|
|
+12K
|
$1.20
|
+$14.73K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
+68K
|
$0.75
|
+$51.26K
|
|
|
SEC
|
Burrows Scott L
|
Chief Financial Officer
|
|
-420
|
$17.75
|
-$7.46K
|
|
|
SEC
|
Lock Kenneth A.
|
Chief Commercial Officer
|
|
-935
|
$17.75
|
-$16.60K
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
-775
|
$17.75
|
-$13.76K
|
|
|
SEC
|
Turney Patricia A.
|
SVP, Operations
|
|
-936
|
$17.75
|
-$16.61K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-2.2K
|
$17.75
|
-$38.22K
|
|
|
SEC
|
Burrows Scott L
|
Chief Financial Officer
|
|
-13K
|
$20.07
|
-$252.08K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-2.5K
|
$20.16
|
-$50.40K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-1K
|
$21.50
|
-$21.50K
|
|
|
SEC
|
CHAUDHURI BHASKAR
|
N/A
|
|
-7.5K
|
$27.50
|
-$205.81K
|
|
|
SEC
|
CHAUDHURI BHASKAR
|
N/A
|
|
-10K
|
$27.50
|
-$275.00K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+1.6K
|
$0.85
|
+$1.37K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-143
|
$18.53
|
-$2.65K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-1.5K
|
$35.00
|
-$52.50K
|
|
|
SEC
|
CHAUDHURI BHASKAR
|
N/A
|
|
-10K
|
$28.06
|
-$280.60K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+2.7K
|
$1.17
|
+$3.11K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-1.8K
|
$29.93
|
-$52.38K
|
|
|
SEC
|
CHAUDHURI BHASKAR
|
N/A
|
|
-10K
|
$31.10
|
-$311.00K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+2.7K
|
$1.17
|
+$3.10K
|
|
|
SEC
|
Smither John W
|
Chief Financial Officer
|
|
-1.3K
|
$25.96
|
-$32.45K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
+31K
|
$1.55
|
+$47.97K
|
|
|
SEC
|
Smither John W
|
Chief Financial Officer
|
|
+22K
|
$0.95
|
+$20.80K
|
|
|
SEC
|
Watanabe Todd Franklin
|
President and CEO
|
|
-2.1K
|
$35.19
|
-$74.15K
|
|
|
SEC
|
Lock Kenneth A.
|
Chief Commercial Officer
|
|
-933
|
$34.20
|
-$31.91K
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
-780
|
$34.57
|
-$26.96K
|
|
|
SEC
|
Smither John W
|
Chief Financial Officer
|
|
-773
|
$34.20
|
-$26.44K
|
|
|
SEC
|
Turney Patricia A.
|
SVP, Operations
|
|
-934
|
$34.52
|
-$32.24K
|
|
|
SEC
|
CHAUDHURI BHASKAR
|
N/A
|
|
-10K
|
$35.52
|
-$355.20K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+2.7K
|
$1.17
|
+$3.11K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+20K
|
$1.68
|
+$33.37K
|
|
|
SEC
|
CHAUDHURI BHASKAR
|
N/A
|
|
-10K
|
$33.22
|
-$332.20K
|
|
|
SEC
|
Smither John W
|
Chief Financial Officer
|
|
-3.8K
|
$28.34
|
-$106.28K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
-2.2K
|
$34.35
|
-$75.57K
|
|
|
SEC
|
Smither John W
|
Chief Financial Officer
|
|
-1.3K
|
$23.71
|
-$29.64K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+1.2K
|
$0.58
|
+$708.76
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
-15K
|
$30.00
|
-$450.00K
|
|
|
SEC
|
Smither John W
|
Chief Financial Officer
|
|
-3.8K
|
$23.71
|
-$88.91K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+1.2K
|
$0.58
|
+$708.76
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+1.2K
|
$0.58
|
+$708.76
|
|
|
SEC
|
Lock Kenneth A.
|
Chief Commercial Officer
|
|
+2.7K
|
$6.52
|
+$17.40K
|
|
|
SEC
|
Lock Kenneth A.
|
Chief Commercial Officer
|
|
+2.7K
|
$6.52
|
+$17.57K
|
|
|
SEC
|
Lock Kenneth A.
|
Chief Commercial Officer
|
|
+7.5K
|
$6.52
|
+$48.90K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+1.2K
|
$0.58
|
+$708.76
|
|
|
SEC
|
OrbiMed Capital GP VII LLC
|
N/A
|
|
+496K
|
$25.00
|
+$12.40M
|
|
|
SEC
|
SILVERSTEIN JONATHAN
|
N/A
|
|
+496K
|
$25.00
|
+$12.40M
|
|
|
SEC
|
OSBORNE DAVID W
|
Chief Technical Officer
|
|
-15K
|
$30.00
|
-$450.00K
|
|
|
SEC
|
Smither John W
|
Chief Financial Officer
|
|
-1.3K
|
$23.71
|
-$29.64K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+1.2K
|
$0.58
|
+$708.76
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+5K
|
$1.68
|
+$8.40K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+5.1K
|
$1.68
|
+$8.53K
|
|
|
SEC
|
Welgus Howard G.
|
N/A
|
|
+6.1K
|
$0.58
|
+$3.54K
|
|
|
SEC
|
Heron Patrick J
|
N/A
|
|
+10M
|
$17.00
|
+$170.57M
|
|
|
SEC
|
OrbiMed Capital GP VII LLC
|
N/A
|
|
+4.7M
|
$17.00
|
+$79.46M
|
|
|
SEC
|
Schwartz Jeffrey Lawrence
|
N/A
|
|
+4M
|
$17.00
|
+$67.65M
|
|
|
SEC
|
SILVERSTEIN JONATHAN
|
N/A
|
|
+4.7M
|
$17.00
|
+$79.46M
|
|
|
SEC
|
Topper James N
|
N/A
|
|
+10M
|
$17.00
|
+$170.57M
|
|