SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-5K
|
$32.10
|
-$160.50K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-30K
|
$30.43
|
-$912.90K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-6.5K
|
$29.18
|
-$189.44K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-97K
|
$32.23
|
-$3.14M
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-5.8K
|
$34.20
|
-$197.33K
|
|
SEC
|
Knight Jeff E.
|
Chief Operating Officer
|
|
-7.2K
|
$34.20
|
-$244.94K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-2.5K
|
$34.20
|
-$86.01K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-17K
|
$34.20
|
-$592.96K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-5K
|
$39.07
|
-$195.35K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-15K
|
$52.09
|
-$781.35K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-10K
|
$57.57
|
-$575.70K
|
|
SEC
|
Knight Jeff E.
|
Chief Operating Officer
|
|
-501
|
$56.52
|
-$28.32K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-14K
|
$54.63
|
-$785.31K
|
|
SEC
|
Wilson Marc
|
CFO
|
|
-25K
|
$51.11
|
-$1.28M
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-1K
|
$51.50
|
-$53.30K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$53.19
|
-$159.57K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$47.68
|
-$143.04K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$53.43
|
-$160.29K
|
|
SEC
|
Wilson Marc
|
CFO
|
|
-19K
|
$53.88
|
-$1.03M
|
|
SEC
|
Knight Jeff E.
|
Chief Operating Officer
|
|
-27K
|
$55.00
|
-$1.49M
|
|
SEC
|
Wilson Marc
|
CFO
|
|
-25K
|
$55.00
|
-$1.38M
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$48.55
|
-$145.65K
|
|
SEC
|
Hassard James
|
Chief Commercial Officer
|
|
-15K
|
$44.08
|
-$661.20K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-14K
|
$44.87
|
-$645.01K
|
|
SEC
|
Wilson Marc
|
CFO
|
|
-32K
|
$43.61
|
-$1.40M
|
|
SEC
|
Knight Jeff E.
|
Chief Operating Officer
|
|
-956
|
$44.38
|
-$42.43K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$45.37
|
-$136.11K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-9.5K
|
$45.73
|
-$434.43K
|
|
SEC
|
Hassard James
|
Chief Commercial Officer
|
|
-15K
|
$44.66
|
-$669.90K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$43.86
|
-$131.58K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$47.49
|
-$142.47K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$49.43
|
-$148.29K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-107K
|
$49.40
|
-$5.31M
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-14K
|
$44.47
|
-$639.26K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-41K
|
$49.17
|
-$2.01M
|
|
SEC
|
Okey Stephanie
|
N/A
|
|
-18K
|
$46.38
|
-$811.65K
|
|
SEC
|
Knight Jeff E.
|
Chief Operating Officer
|
|
-32K
|
$44.31
|
-$1.43M
|
|
SEC
|
Fust Matthew K
|
N/A
|
|
-60K
|
$44.14
|
-$2.65M
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-15K
|
$44.06
|
-$664.82K
|
|
SEC
|
Wilson Marc
|
CFO
|
|
-6.9K
|
$42.91
|
-$297.88K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$37.26
|
-$111.78K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$37.65
|
-$112.95K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-14K
|
$35.00
|
-$503.13K
|
|
SEC
|
Wilson Marc
|
CFO
|
|
-10K
|
$35.47
|
-$354.70K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$35.89
|
-$107.67K
|
|
SEC
|
Pizzuti Dana
|
Chief Med and Dev Officer
|
|
-9.6K
|
$34.57
|
-$331.28K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$32.87
|
-$98.61K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$31.84
|
-$95.52K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-200K
|
$30.56
|
-$6.11M
|
|
SEC
|
Wilson Marc
|
CFO
|
|
-10K
|
$28.75
|
-$287.50K
|
|
SEC
|
Krasner Alan Seth
|
Chief Medical Officer
|
|
-7K
|
$30.00
|
-$210.00K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-50K
|
$20.21
|
-$1.01M
|
|
SEC
|
Wilson Marc
|
CFO
|
|
-31K
|
$19.97
|
-$617.51K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-50K
|
$20.81
|
-$1.04M
|
|
SEC
|
Vivaldi Coelho Rogerio
|
N/A
|
|
+5K
|
$22.06
|
+$110.30K
|
|
SEC
|
Pizzuti Dana
|
Chief Development Officer
|
|
-8.2K
|
$16.15
|
-$132.62K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$19.59
|
-$61.24K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-8.3K
|
$21.07
|
-$175.64K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$18.00
|
-$56.27K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$18.35
|
-$57.36K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$16.00
|
-$50.02K
|
|
SEC
|
Knight Jeff E.
|
Chief Operating Officer
|
|
+537
|
$15.16
|
+$8.14K
|
|
SEC
|
Krasner Alan Seth
|
Chief Medical Officer
|
|
+1.9K
|
$11.02
|
+$21.24K
|
|
SEC
|
Wilson Marc
|
CFO
|
|
+1.9K
|
$11.02
|
+$21.25K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$18.52
|
-$57.89K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
+11K
|
$1.91
|
+$21.20K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$19.64
|
-$61.39K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-4.2K
|
$21.01
|
-$87.57K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-1K
|
$21.00
|
-$21.88K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$18.59
|
-$58.11K
|
|
SEC
|
Knight Jeff E.
|
Chief Operating Officer
|
|
-1.2K
|
$20.70
|
-$23.85K
|
|
SEC
|
Fust Matthew K
|
N/A
|
|
-5.7K
|
$20.96
|
-$119.47K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.2K
|
$20.10
|
-$65.26K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-5.7K
|
$25.81
|
-$146.19K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+158K
|
$22.22
|
+$3.50M
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-139K
|
$26.83
|
-$3.72M
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-21K
|
$25.34
|
-$541.19K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-9K
|
$23.97
|
-$215.73K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-8.3K
|
$21.43
|
-$178.47K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$18.94
|
-$59.15K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
+13K
|
$3.14
|
+$42.00K
|
|
SEC
|
Madan Ajay
|
Chief Development Officer
|
|
+23K
|
$7.80
|
+$179.01K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$18.64
|
-$58.21K
|
|
SEC
|
Madan Ajay
|
Chief Development Officer
|
|
-13K
|
$17.83
|
-$239.12K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3.1K
|
$18.79
|
-$58.68K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-4.2K
|
$23.29
|
-$97.07K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-7.2K
|
$28.02
|
-$200.85K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$27.95
|
-$83.85K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-5.7K
|
$24.14
|
-$136.83K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-5.7K
|
$27.38
|
-$155.19K
|
|
SEC
|
Madan Ajay
|
Chief Development Officer
|
|
+785
|
$11.02
|
+$8.65K
|
|
SEC
|
Wilson Marc
|
CFO
|
|
+1.9K
|
$11.02
|
+$21.24K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-7.2K
|
$27.01
|
-$193.61K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-17K
|
$28.06
|
-$462.99K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-5.7K
|
$24.79
|
-$140.51K
|
|
SEC
|
Madan Ajay
|
Chief Development Officer
|
|
+106K
|
$0.73
|
+$77.66K
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-3K
|
$24.00
|
-$72.00K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+1.2M
|
$19.80
|
+$23.76M
|
|
SEC
|
Betz Stephen F.
|
Chief Scientific Officer
|
|
-1K
|
$21.10
|
-$21.99K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-30K
|
$25.00
|
-$750.00K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+304K
|
$16.44
|
+$5.00M
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
+5K
|
$13.00
|
+$65.00K
|
|
SEC
|
Krasner Alan Seth
|
Chief Medical Officer
|
|
+1.4K
|
$13.90
|
+$20.04K
|
|
SEC
|
Wilson Marc
|
CFO and Secretary
|
|
+1.4K
|
$13.02
|
+$18.21K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
-35K
|
$14.88
|
-$520.80K
|
|
SEC
|
Madan Ajay
|
Chief Development Officer
|
|
+1.5K
|
$14.45
|
+$21.24K
|
|
SEC
|
WIERENGA WENDALL
|
N/A
|
|
+25K
|
$0.73
|
+$18.49K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+1.1M
|
$14.00
|
+$15.00M
|
|
SEC
|
Vivo Capital Surplus Fund VIII, L.P.
|
N/A
|
|
-331K
|
$15.45
|
-$5.11M
|
|
SEC
|
Vivo Capital Surplus Fund VIII, L.P.
|
N/A
|
|
-306K
|
$13.81
|
-$4.23M
|
|
SEC
|
Vivo Opportunity Fund, L.P.
|
N/A
|
|
-528
|
$19.50
|
-$10.30K
|
|
SEC
|
Vivo Opportunity Fund, L.P.
|
N/A
|
|
-13K
|
$21.66
|
-$291.54K
|
|
SEC
|
Vivo Opportunity Fund, L.P.
|
N/A
|
|
-13K
|
$22.80
|
-$306.89K
|
|
SEC
|
Vivo Opportunity Fund, L.P.
|
N/A
|
|
-27K
|
$22.07
|
-$594.12K
|
|
SEC
|
Struthers Richard Scott
|
President & CEO
|
|
+10K
|
$0.01
|
+$100.00
|
|
SEC
|
Schwab Andrew J.
|
N/A
|
|
-250K
|
$22.20
|
-$5.55M
|
|
SEC
|
Krasner Alan Seth
|
Chief Medical Officer
|
|
+1.5K
|
$14.45
|
+$21.26K
|
|
SEC
|
Wilson Marc
|
CFO and Secretary
|
|
+1.5K
|
$14.45
|
+$21.26K
|
|
SEC
|
Vivo Opportunity Fund, L.P.
|
N/A
|
|
-417K
|
$22.25
|
-$9.28M
|
|
SEC
|
Schwab Andrew J.
|
N/A
|
|
-155K
|
$24.25
|
-$3.75M
|
|
SEC
|
Schwab Andrew J.
|
N/A
|
|
-262K
|
$21.88
|
-$5.74M
|
|
SEC
|
Krasner Alan Seth
|
Chief Medical Officer
|
|
+1.5K
|
$14.45
|
+$21.24K
|
|
SEC
|
Wilson Marc
|
See Remarks
|
|
+1.5K
|
$14.45
|
+$21.24K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+2.3M
|
$17.00
|
+$38.77M
|
|
SEC
|
Krasner Alan Seth
|
Chief Medical Officer
|
|
+2K
|
$17.00
|
+$34.00K
|
|
SEC
|
Schwab Andrew J.
|
N/A
|
|
+3.5M
|
$17.00
|
+$59.49M
|
|
SEC
|
Vivo Opportunity Fund, L.P.
|
N/A
|
|
+3.7M
|
$18.62
|
+$69.59M
|
|