SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
-12K
|
$6.23
|
-$74.57K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
-19M
|
$6.23
|
-$119.78M
|
|
SEC
|
Johnson Craig A
|
N/A
|
|
-12K
|
$6.23
|
-$74.76K
|
|
SEC
|
Johnson Laura L.
|
N/A
|
|
-500
|
$6.23
|
-$3.12K
|
|
SEC
|
RAMSAY DAVID A
|
N/A
|
|
-100K
|
$6.23
|
-$623.00K
|
|
SEC
|
TANG KEVIN C
|
N/A
|
|
-19M
|
$6.23
|
-$119.71M
|
|
SEC
|
Johnson Craig A
|
N/A
|
|
+12K
|
$3.93
|
+$47.16K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+236
|
$2.71
|
+$639.56
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+236
|
$2.72
|
+$641.92
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+189
|
$3.41
|
+$644.49
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+188
|
$3.41
|
+$641.08
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+185
|
$3.47
|
+$641.95
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+296
|
$3.71
|
+$1.10K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+173
|
$3.71
|
+$641.83
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+334
|
$3.63
|
+$1.21K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+177
|
$3.63
|
+$642.51
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+361
|
$3.37
|
+$1.22K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+190
|
$3.37
|
+$640.30
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+350
|
$3.48
|
+$1.22K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+185
|
$3.48
|
+$643.80
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+320
|
$3.79
|
+$1.21K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+169
|
$3.79
|
+$640.51
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+4.2K
|
$3.94
|
+$16.43K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+1.7K
|
$3.94
|
+$6.60K
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+273
|
$4.18
|
+$1.14K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+148
|
$4.18
|
+$618.64
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+233
|
$3.92
|
+$913.36
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+157
|
$3.92
|
+$615.44
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+320
|
$3.58
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+173
|
$3.58
|
+$619.34
|
|
SEC
|
RAMSAY DAVID A
|
N/A
|
|
+25K
|
$3.75
|
+$91.88K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
-441K
|
$3.93
|
-$1.73M
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+346
|
$3.32
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+186
|
$3.32
|
+$617.52
|
|
SEC
|
RAMSAY DAVID A
|
N/A
|
|
+7.5K
|
$4.23
|
+$31.73K
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+336
|
$3.41
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+181
|
$3.41
|
+$617.21
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+335
|
$3.42
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+181
|
$3.42
|
+$619.02
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+341
|
$3.37
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+183
|
$3.37
|
+$616.71
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+338
|
$3.39
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+182
|
$3.39
|
+$616.98
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+338
|
$3.39
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+546
|
$3.39
|
+$1.85K
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+320
|
$3.58
|
+$1.15K
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+338
|
$3.38
|
+$1.14K
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+374
|
$3.07
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+201
|
$3.07
|
+$617.07
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+358
|
$3.20
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+193
|
$3.20
|
+$617.60
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+315
|
$3.64
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+170
|
$3.64
|
+$618.80
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+275
|
$4.17
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+148
|
$4.17
|
+$617.16
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+245K
|
$4.47
|
+$1.10M
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+314
|
$3.65
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+169
|
$3.66
|
+$618.54
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+399K
|
$3.96
|
+$1.58M
|
|
SEC
|
RAMSAY DAVID A
|
N/A
|
|
+20K
|
$3.49
|
+$69.80K
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+358
|
$3.20
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+193
|
$3.20
|
+$617.60
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+304
|
$3.77
|
+$1.15K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+163
|
$3.77
|
+$614.51
|
|
SEC
|
Edwards Larry G.
|
Chief Executive Officer
|
|
+322
|
$3.55
|
+$1.14K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+173
|
$3.55
|
+$614.15
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+172
|
$3.60
|
+$619.20
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+127
|
$4.85
|
+$615.95
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+139
|
$4.45
|
+$618.55
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+535
|
$5.70
|
+$3.05K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+118
|
$5.20
|
+$613.60
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+136
|
$4.55
|
+$618.80
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+171
|
$3.30
|
+$564.30
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+147
|
$3.83
|
+$563.01
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+134
|
$4.22
|
+$565.48
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+141
|
$3.98
|
+$561.18
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+196
|
$2.89
|
+$566.44
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+169
|
$3.32
|
+$561.08
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+286
|
$3.85
|
+$1.10K
|
|
SEC
|
RAMSAY DAVID A
|
N/A
|
|
+1K
|
$3.83
|
+$3.83K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+550
|
$3.57
|
+$1.96K
|
|
SEC
|
RAMSAY DAVID A
|
N/A
|
|
+47K
|
$3.99
|
+$187.53K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+589
|
$3.34
|
+$1.97K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+432K
|
$3.72
|
+$1.61M
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+581
|
$3.38
|
+$1.96K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+521
|
$3.77
|
+$1.96K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+543
|
$3.62
|
+$1.97K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+435
|
$4.51
|
+$1.96K
|
|
SEC
|
Hearne Michael S
|
Chief Financial Officer
|
|
+615K
|
$4.91
|
+$3.02M
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+491
|
$4.01
|
+$1.97K
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+82
|
$4.01
|
+$328.82
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+205
|
$4.01
|
+$822.05
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+335
|
$5.86
|
+$1.96K
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+56
|
$5.86
|
+$328.16
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+140
|
$5.86
|
+$820.40
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+319
|
$6.17
|
+$1.97K
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+53
|
$6.17
|
+$327.01
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+133
|
$6.17
|
+$820.61
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+350
|
$5.61
|
+$1.96K
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+58
|
$5.61
|
+$325.38
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+146
|
$5.61
|
+$819.06
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+34
|
$5.61
|
+$190.74
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+165
|
$3.57
|
+$589.05
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+229
|
$3.57
|
+$817.53
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+459
|
$3.57
|
+$1.64K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+173
|
$3.40
|
+$588.20
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+241
|
$3.40
|
+$819.40
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+483
|
$3.40
|
+$1.64K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+102
|
$5.78
|
+$589.56
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+142
|
$5.78
|
+$820.76
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+284
|
$5.78
|
+$1.64K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+83
|
$7.14
|
+$592.62
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+115
|
$7.14
|
+$821.10
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+229
|
$7.14
|
+$1.64K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+170K
|
$6.76
|
+$1.15M
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+101
|
$5.82
|
+$587.82
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+141
|
$5.82
|
+$820.62
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+282
|
$5.82
|
+$1.64K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+498
|
$6.70
|
+$3.34K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+692
|
$6.70
|
+$4.64K
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+1.2K
|
$6.70
|
+$7.96K
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+3K
|
$8.23
|
+$24.69K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+3M
|
$5.87
|
+$17.44M
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+172
|
$3.34
|
+$574.48
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+16
|
$3.34
|
+$53.44
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+201
|
$2.85
|
+$572.85
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+112
|
$2.85
|
+$319.20
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+247
|
$2.33
|
+$575.51
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+138
|
$2.33
|
+$321.54
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+17
|
$2.33
|
+$39.61
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+111
|
$5.12
|
+$568.32
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+62
|
$5.12
|
+$317.44
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+118
|
$5.12
|
+$604.16
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+311
|
$5.12
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+96
|
$5.96
|
+$572.16
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+267
|
$5.96
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+133
|
$5.96
|
+$792.68
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+267
|
$5.96
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+81
|
$7.12
|
+$576.72
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+224
|
$7.12
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+112
|
$7.12
|
+$797.44
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+224
|
$7.12
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+76
|
$7.48
|
+$568.48
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+213
|
$7.48
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+107
|
$7.48
|
+$800.36
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+213
|
$7.48
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+62
|
$9.28
|
+$575.36
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+171
|
$9.28
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+85
|
$9.28
|
+$788.80
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+171
|
$9.28
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+70
|
$8.13
|
+$569.10
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+196
|
$8.13
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+98
|
$8.13
|
+$796.74
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+196
|
$8.13
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+72
|
$8.02
|
+$577.44
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+198
|
$8.02
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+99
|
$8.02
|
+$793.98
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+198
|
$8.02
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+80
|
$7.11
|
+$568.80
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+224
|
$7.11
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+112
|
$7.11
|
+$796.32
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+224
|
$7.11
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+73
|
$7.86
|
+$573.78
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+202
|
$7.86
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+101
|
$7.86
|
+$793.86
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+202
|
$7.86
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+69
|
$8.25
|
+$569.25
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+193
|
$8.25
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+96
|
$8.25
|
+$792.00
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+193
|
$8.25
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+126
|
$4.58
|
+$577.08
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+347
|
$4.58
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+174
|
$4.58
|
+$796.92
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+347
|
$4.58
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+102
|
$5.58
|
+$569.16
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+285
|
$5.58
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+143
|
$5.58
|
+$797.94
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+285
|
$5.58
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+84
|
$6.84
|
+$574.56
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+233
|
$6.84
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+116
|
$6.84
|
+$793.44
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+233
|
$6.84
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+94
|
$6.09
|
+$572.46
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+261
|
$6.09
|
+$1.59K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+131
|
$6.09
|
+$797.79
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+2
|
$6.09
|
+$12.18
|
|
SEC
|
Wellinghoff Darryl
|
Chief Commercial Officer
|
|
+261
|
$6.09
|
+$1.59K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+35
|
$5.47
|
+$191.45
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+59
|
$5.47
|
+$322.73
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+146
|
$5.47
|
+$798.62
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+94
|
$5.47
|
+$514.18
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+29
|
$6.49
|
+$188.21
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+49
|
$6.49
|
+$318.01
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+122
|
$6.49
|
+$791.78
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+195
|
$6.49
|
+$1.27K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+230
|
$4.85
|
+$1.12K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+40
|
$4.85
|
+$194.00
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+65
|
$4.85
|
+$315.25
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+164
|
$4.85
|
+$795.40
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+261
|
$4.85
|
+$1.27K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+230
|
$5.30
|
+$1.22K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+36
|
$5.30
|
+$190.80
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+60
|
$5.30
|
+$318.00
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+151
|
$5.30
|
+$800.30
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+239
|
$5.30
|
+$1.27K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+1.3K
|
$5.13
|
+$6.46K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+37
|
$5.13
|
+$189.81
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+63
|
$5.13
|
+$323.19
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+155
|
$5.13
|
+$795.15
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+246
|
$5.13
|
+$1.26K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+3K
|
$5.56
|
+$16.68K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+213
|
$5.74
|
+$1.22K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+72
|
$5.74
|
+$413.28
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+316
|
$5.74
|
+$1.81K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+792
|
$5.74
|
+$4.55K
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+874
|
$5.74
|
+$5.02K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+5K
|
$6.17
|
+$30.85K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+1.6K
|
$6.09
|
+$9.74K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+1.3M
|
$5.37
|
+$6.98M
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
-2.1M
|
$5.69
|
-$11.72M
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+2K
|
$5.85
|
+$11.70K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+148
|
$8.02
|
+$1.19K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+23
|
$8.02
|
+$184.46
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+39
|
$8.02
|
+$312.78
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+97
|
$8.02
|
+$777.94
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+154
|
$8.02
|
+$1.24K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+108
|
$10.88
|
+$1.18K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+17
|
$10.88
|
+$184.96
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+28
|
$10.88
|
+$304.64
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+70
|
$10.88
|
+$761.60
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+112
|
$10.88
|
+$1.22K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+96
|
$12.30
|
+$1.18K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+16
|
$12.30
|
+$196.80
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+26
|
$12.30
|
+$319.80
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+63
|
$12.30
|
+$774.90
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+100
|
$12.30
|
+$1.23K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+94
|
$12.67
|
+$1.19K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+16
|
$12.67
|
+$202.72
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+24
|
$12.67
|
+$304.08
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+61
|
$12.67
|
+$772.87
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+97
|
$12.67
|
+$1.23K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+85
|
$13.85
|
+$1.18K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+15
|
$13.86
|
+$207.90
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+22
|
$13.86
|
+$304.92
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+56
|
$13.86
|
+$776.16
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+89
|
$13.86
|
+$1.23K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+1K
|
$20.90
|
+$20.90K
|
|
SEC
|
Rolke James
|
Chief Scientific Officer
|
|
+1K
|
$22.00
|
+$22.00K
|
|
SEC
|
Douglass Laura L.
|
N/A
|
|
+500
|
$6.00
|
+$3.00K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+700K
|
$29.50
|
+$20.65M
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+508K
|
$29.50
|
+$15.00M
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+40K
|
$30.06
|
+$1.20M
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+150K
|
$31.82
|
+$4.77M
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+1K
|
$32.48
|
+$32.48K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+50K
|
$32.42
|
+$1.62M
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+175K
|
$32.72
|
+$5.73M
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+1K
|
$33.22
|
+$33.22K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+149K
|
$33.50
|
+$5.00M
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+1.6K
|
$34.80
|
+$55.68K
|
|
SEC
|
MULROY DENNIS
|
Chief Financial Officer
|
|
+500
|
$33.95
|
+$16.98K
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+3K
|
$34.17
|
+$102.51K
|
|
SEC
|
CARVER JENNIFER
|
Chief Operating Officer
|
|
+1K
|
$34.46
|
+$34.46K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+100K
|
$34.64
|
+$3.46M
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+139K
|
$19.82
|
+$2.76M
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+20K
|
$19.85
|
+$397.00K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+160K
|
$17.82
|
+$2.85M
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+2K
|
$16.57
|
+$33.14K
|
|
SEC
|
Chawla Lakhmir S
|
Chief Medical Officer
|
|
+485
|
$27.75
|
+$13.46K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+80K
|
$38.00
|
+$3.04M
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+170K
|
$27.11
|
+$4.61M
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+110K
|
$23.58
|
+$2.59M
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+220K
|
$22.23
|
+$4.89M
|
|
SEC
|
Zarrabian Saiid
|
N/A
|
|
+307
|
$19.50
|
+$5.99K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+191K
|
$18.24
|
+$3.48M
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+4K
|
$18.37
|
+$73.48K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+582
|
$13.95
|
+$8.12K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+232K
|
$12.84
|
+$2.98M
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+4K
|
$11.38
|
+$45.52K
|
|
SEC
|
TANG CAPITAL MANAGEMENT LLC
|
N/A
|
|
+170K
|
$9.14
|
+$1.55M
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+2K
|
$9.35
|
+$18.70K
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+5K
|
$9.18
|
+$45.90K
|
|
SEC
|
Zarrabian Saiid
|
N/A
|
|
+381
|
$9.53
|
+$3.63K
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+19K
|
$10.50
|
+$199.50K
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+12K
|
$7.37
|
+$88.44K
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+8K
|
$9.53
|
+$76.24K
|
|
SEC
|
TIDMARSH GEORGE F
|
President, CEO & Secretary
|
|
+3K
|
$7.25
|
+$21.75K
|
|
SEC
|
Reinisch Richard
|
N/A
|
|
+1.1M
|
$0.11
|
+$121.00K
|
|
SEC
|
Gillespie Deirdre
|
President & CEO
|
|
-99K
|
$0.02
|
-$1.98K
|
|
SEC
|
SLOAN GAIL A
|
Chief Financial Officer
|
|
-100
|
$1.00
|
-$100.00
|
|
SEC
|
Gillespie Deirdre
|
President & CEO
|
|
-4.4K
|
$0.70
|
-$3.06K
|
|
SEC
|
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP
|
N/A
|
|
-1.1M
|
$0.19
|
-$201.52K
|
|
SEC
|
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P
|
N/A
|
|
-1.2M
|
$0.19
|
-$220.74K
|
|
SEC
|
SLOAN GAIL A
|
VP of Finance
|
|
-1.8K
|
$0.19
|
-$343.90
|
|
SEC
|
SUTTER MARTIN P
|
N/A
|
|
-2.2M
|
$0.19
|
-$425.68K
|
|
SEC
|
SUTTER MARTIN P
|
N/A
|
|
-113K
|
$0.18
|
-$20.32K
|
|
SEC
|
SLOAN GAIL A
|
VP of Finance
|
|
-2.2K
|
$0.18
|
-$401.40
|
|
SEC
|
BIOMARIN PHARMACEUTICAL INC
|
N/A
|
|
-5.7M
|
$0.21
|
-$1.20M
|
|
SEC
|
SLOAN GAIL A
|
VP of Finance
|
|
-4.9K
|
$0.20
|
-$982.80
|
|
SEC
|
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP
|
N/A
|
|
-6.7M
|
$0.06
|
-$404.81K
|
|
SEC
|
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P
|
N/A
|
|
-8.6M
|
$0.06
|
-$515.21K
|
|
SEC
|
FILDES ROBERT PHD
|
N/A
|
|
-17K
|
$0.05
|
-$830.60
|
|
SEC
|
SMITH CRAIG R
|
N/A
|
|
-27K
|
$0.06
|
-$1.63K
|
|
SEC
|
Topper James N
|
N/A
|
|
-5.9M
|
$0.06
|
-$352.36K
|
|
SEC
|
Elchico Josefina T
|
VP Quality Operations
|
|
-26K
|
$0.10
|
-$2.58K
|
|
SEC
|
FHM V, LP
|
N/A
|
|
-1.7M
|
$0.07
|
-$116.34K
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
-8.2M
|
$0.20
|
-$1.64M
|
|
SEC
|
SUTTER MARTIN P
|
N/A
|
|
+38K
|
$1.41
|
+$53.32K
|
|
SEC
|
ESSEX WOODLANDS HEALTH VENTURES FUND VII LP
|
N/A
|
|
+7.8M
|
$1.89
|
+$14.76M
|
|
SEC
|
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P
|
N/A
|
|
+2.1M
|
$1.89
|
+$3.93M
|
|
SEC
|
Frazier Healthcare V, LP
|
N/A
|
|
+1M
|
$1.89
|
+$1.96M
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
+1.6M
|
$1.89
|
+$3.06M
|
|
SEC
|
SUTTER MARTIN P
|
N/A
|
|
+9.9M
|
$1.89
|
+$18.69M
|
|
SEC
|
Elchico Josefina T
|
VP Quality Operations
|
|
-400
|
$3.90
|
-$1.56K
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
+50K
|
$3.93
|
+$196.50K
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
+58K
|
$3.65
|
+$209.90K
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
+75K
|
$4.45
|
+$333.75K
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
+13K
|
$4.27
|
+$55.51K
|
|
SEC
|
ESSEX WOODLANDS HEALTH VENTURES FUND VI L P
|
N/A
|
|
+1M
|
$6.00
|
+$6.00M
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
+833K
|
$6.00
|
+$5.00M
|
|
SEC
|
Naini Nader J
|
N/A
|
|
+833K
|
$6.00
|
+$5.00M
|
|
SEC
|
SUTTER MARTIN P
|
N/A
|
|
+1M
|
$6.00
|
+$6.00M
|
|
SEC
|
Topper James N
|
N/A
|
|
+833K
|
$6.00
|
+$5.00M
|
|
SEC
|
FHM V, LP
|
N/A
|
|
+833K
|
$6.00
|
+$5.00M
|
|
SEC
|
TANSEY MICHAEL JAMES BYRON
|
Executive VP & CMO
|
|
+1.9K
|
$3.11
|
+$5.91K
|
|
SEC
|
JENN PAUL
|
VP of Product Development
|
|
-6.6K
|
$3.09
|
-$20.49K
|
|
SEC
|
KOCH LISA I
|
Sr Dir Regulatory Affairs
|
|
-4.2K
|
$3.04
|
-$12.62K
|
|
SEC
|
KOCH LISA I
|
Sr Dir Regulatory Affairs
|
|
-1.2K
|
$3.02
|
-$3.57K
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
+192K
|
$3.32
|
+$636.02K
|
|
SEC
|
JENN PAUL
|
VP of Product Development
|
|
-5K
|
$3.11
|
-$15.55K
|
|
SEC
|
LINNIK MATTHEW D
|
CSO & Exec VP of Research
|
|
-5.4K
|
$2.89
|
-$15.50K
|
|
SEC
|
Naini Nader J
|
N/A
|
|
+20M
|
$0.75
|
+$15.00M
|
|
SEC
|
SUTTER MARTIN P
|
N/A
|
|
+33M
|
$0.75
|
+$25.00M
|
|
SEC
|
Topper James N
|
N/A
|
|
+20M
|
$0.75
|
+$15.00M
|
|
SEC
|
Gonzalez Alejandro
|
N/A
|
|
+77K
|
$1.50
|
+$115.50K
|
|
SEC
|
SLOAN GAIL A
|
VP of Finance/Controller
|
|
+250
|
$2.72
|
+$680.00
|
|
SEC
|
ENGLE STEVEN B
|
CEO & Chairman
|
|
-141K
|
$3.00
|
-$423.00K
|
|