SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-17K
|
$105.30
|
-$1.77M
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-4.2K
|
$100.07
|
-$419.09K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-28K
|
$96.29
|
-$2.70M
|
|
SEC
|
German Christopher Paul
|
Corporate Controller & CAO
|
|
-1.5K
|
$95.00
|
-$142.50K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-4K
|
$90.08
|
-$358.88K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-1.5K
|
$85.93
|
-$130.61K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-16K
|
$77.13
|
-$1.20M
|
|
SEC
|
German Christopher Paul
|
Corporate Controller & CAO
|
|
-3.8K
|
$80.75
|
-$308.22K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-8K
|
$77.78
|
-$619.83K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-42K
|
$80.48
|
-$3.39M
|
|
SEC
|
Garfield Alastair
|
Chief Scientific Officer
|
|
-1.3K
|
$64.81
|
-$85.48K
|
|
SEC
|
German Christopher Paul
|
Corporate Controller & CAO
|
|
-2.1K
|
$67.19
|
-$139.02K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-7K
|
$68.05
|
-$478.46K
|
|
SEC
|
MCGIRR DAVID W J
|
N/A
|
|
-65K
|
$65.22
|
-$4.27M
|
|
SEC
|
Meeker David P
|
President and CEO
|
|
-44K
|
$65.05
|
-$2.84M
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-23K
|
$61.41
|
-$1.44M
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-7K
|
$65.09
|
-$457.65K
|
|
SEC
|
Mazabraud Yann
|
EVP, Head of International
|
|
-6.7K
|
$65.08
|
-$438.96K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-21K
|
$60.14
|
-$1.25M
|
|
SEC
|
Mazabraud Yann
|
EVP, Head of International
|
|
-18K
|
$60.99
|
-$1.08M
|
|
SEC
|
German Christopher Paul
|
Corporate Controller & CAO
|
|
-344
|
$54.23
|
-$18.66K
|
|
SEC
|
Mazabraud Yann
|
EVP, Head of International
|
|
-75K
|
$51.48
|
-$3.86M
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-982
|
$57.22
|
-$56.19K
|
|
SEC
|
German Christopher Paul
|
Corporate Controller & CAO
|
|
-635
|
$57.22
|
-$36.33K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-2K
|
$57.22
|
-$116.44K
|
|
SEC
|
Meeker David P
|
President and CEO
|
|
-9.9K
|
$57.22
|
-$566.25K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-1.2K
|
$57.22
|
-$70.27K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-2.2K
|
$57.22
|
-$126.74K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-3K
|
$57.03
|
-$172.23K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-469
|
$56.40
|
-$26.45K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-751
|
$56.39
|
-$42.35K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-701
|
$57.51
|
-$40.31K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-5.2K
|
$58.64
|
-$305.87K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-794
|
$57.51
|
-$45.66K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-1.3K
|
$57.51
|
-$74.53K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-3.1K
|
$60.55
|
-$185.65K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-902
|
$59.43
|
-$53.61K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-1.4K
|
$59.43
|
-$86.00K
|
|
SEC
|
Meeker David P
|
President and CEO
|
|
-4.3K
|
$59.43
|
-$254.24K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-1.3K
|
$59.43
|
-$76.13K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-1.7K
|
$59.43
|
-$99.72K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-67K
|
$66.33
|
-$4.43M
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-13K
|
$66.44
|
-$882.39K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-9.4K
|
$62.50
|
-$585.94K
|
|
SEC
|
GOOD JENNIFER L
|
N/A
|
|
-32K
|
$52.40
|
-$1.66M
|
|
SEC
|
TETRAULT LYNN A.
|
N/A
|
|
-21K
|
$49.71
|
-$1.03M
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-4.1K
|
$50.03
|
-$205.07K
|
|
SEC
|
GOOD JENNIFER L
|
N/A
|
|
-37K
|
$50.45
|
-$1.88M
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-3.2K
|
$50.01
|
-$160.03K
|
|
SEC
|
GOOD JENNIFER L
|
N/A
|
|
-15K
|
$50.01
|
-$725.55K
|
|
SEC
|
TETRAULT LYNN A.
|
N/A
|
|
-4.3K
|
$50.01
|
-$215.04K
|
|
SEC
|
TETRAULT LYNN A.
|
N/A
|
|
-10K
|
$44.65
|
-$446.50K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-49K
|
$45.15
|
-$2.21M
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-1.4K
|
$49.06
|
-$68.44K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-10K
|
$53.00
|
-$554.80K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-5.3K
|
$50.01
|
-$265.70K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-4K
|
$38.47
|
-$153.26K
|
|
SEC
|
German Christopher Paul
|
Corporate Controller & CAO
|
|
-368
|
$41.76
|
-$15.37K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-18K
|
$40.34
|
-$735.60K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-18K
|
$38.77
|
-$706.97K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-16K
|
$39.22
|
-$608.50K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-16K
|
$39.22
|
-$608.50K
|
|
SEC
|
Mazabraud Yann
|
EVP, Head of International
|
|
-16K
|
$39.22
|
-$627.52K
|
|
SEC
|
Meeker David P
|
President and CEO
|
|
-45K
|
$39.22
|
-$1.78M
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-16K
|
$39.22
|
-$608.50K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-16K
|
$39.22
|
-$608.50K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-3K
|
$50.00
|
-$147.70K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-1.6K
|
$50.80
|
-$83.21K
|
|
SEC
|
Mazabraud Yann
|
EVP, Head of International
|
|
-2.6K
|
$50.80
|
-$129.59K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-73K
|
$50.39
|
-$3.68M
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-1.9K
|
$50.80
|
-$97.43K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-696
|
$51.38
|
-$35.76K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-946
|
$45.06
|
-$42.63K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-1.5K
|
$45.06
|
-$67.23K
|
|
SEC
|
Meeker David P
|
President and CEO
|
|
-4.4K
|
$45.06
|
-$196.51K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-1.3K
|
$45.06
|
-$59.66K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-1.6K
|
$45.06
|
-$72.82K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-13K
|
$50.00
|
-$647.05K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-27K
|
$38.72
|
-$1.05M
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-11K
|
$35.02
|
-$384.31K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-14K
|
$32.01
|
-$437.80K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
-28K
|
$32.07
|
-$894.43K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
-12K
|
$30.38
|
-$364.56K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-9.2K
|
$28.45
|
-$260.32K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-80
|
$28.00
|
-$2.24K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-6.2K
|
$28.05
|
-$172.96K
|
|
SEC
|
Lee Jennifer Kayden
|
EVP, Head of North America
|
|
-13K
|
$24.24
|
-$313.69K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
-930
|
$17.64
|
-$16.41K
|
|
SEC
|
Roberts William T.
|
Chief Accounting Officer
|
|
-912
|
$17.50
|
-$15.96K
|
|
SEC
|
Chien Jennifer
|
EVP, Head of North America
|
|
+1.4K
|
$26.87
|
+$37.51K
|
|
SEC
|
Mazabraud Yann
|
EVP, Head of International
|
|
-1.2K
|
$27.03
|
-$31.81K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
+1K
|
$26.87
|
+$27.11K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+1.6K
|
$26.87
|
+$44.12K
|
|
SEC
|
Chien Jennifer
|
EVP, Head of North America
|
|
+2.2K
|
$27.66
|
+$62.12K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
+1.5K
|
$27.66
|
+$41.77K
|
|
SEC
|
Mazabraud Yann
|
EVP, Head of International
|
|
+1.9K
|
$27.66
|
+$52.28K
|
|
SEC
|
Roberts William T.
|
Chief Accounting Officer
|
|
+1.4K
|
$27.66
|
+$37.45K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
+1.7K
|
$27.66
|
+$48.02K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+2.7K
|
$27.66
|
+$73.71K
|
|
SEC
|
Cramer Pamela J.
|
Chief Human Resources Officer
|
|
+2.2K
|
$11.68
|
+$25.98K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+17K
|
$4.08
|
+$71.21K
|
|
SEC
|
Roberts William T.
|
Chief Accounting Officer
|
|
-1K
|
$11.13
|
-$11.39K
|
|
SEC
|
Chien Jennifer
|
EVP, Head of North America
|
|
+1.3K
|
$6.10
|
+$7.99K
|
|
SEC
|
Mazabraud Yann
|
EVP, Head of International
|
|
+1.1K
|
$6.10
|
+$6.70K
|
|
SEC
|
Shulman Joseph
|
Chief Technical Officer
|
|
+1K
|
$6.10
|
+$6.14K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+1.5K
|
$6.10
|
+$9.22K
|
|
SEC
|
Meeker David P
|
President and CEO
|
|
+10K
|
$20.17
|
+$201.70K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-1M
|
$25.10
|
-$25.10M
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+4K
|
$6.88
|
+$27.52K
|
|
SEC
|
Shah Rajeev M.
|
N/A
|
|
-239K
|
$29.47
|
-$7.03M
|
|
SEC
|
Desikan Nithya
|
Chief Commercial Officer
|
|
+15K
|
$6.88
|
+$99.99K
|
|
SEC
|
Shah Rajeev M.
|
N/A
|
|
-132K
|
$22.06
|
-$2.90M
|
|
SEC
|
Shah Rajeev M.
|
N/A
|
|
-150K
|
$23.05
|
-$3.46M
|
|
SEC
|
Foley Todd
|
N/A
|
|
-300
|
$25.04
|
-$7.51K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-115K
|
$25.35
|
-$2.92M
|
|
SEC
|
Foley Todd
|
N/A
|
|
-1.9K
|
$20.00
|
-$37.92K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-44K
|
$20.21
|
-$896.48K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-29K
|
$20.17
|
-$590.98K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-97K
|
$20.32
|
-$1.97M
|
|
SEC
|
Foley Todd
|
N/A
|
|
-35K
|
$20.00
|
-$690.18K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-1.8K
|
$20.04
|
-$36.81K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-53K
|
$20.25
|
-$1.08M
|
|
SEC
|
Foley Todd
|
N/A
|
|
-1.8K
|
$20.00
|
-$36.52K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-36K
|
$20.10
|
-$728.08K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-35K
|
$15.13
|
-$523.04K
|
|
SEC
|
Smith Hunter C
|
CFO and Interim CEO
|
|
+3.9K
|
$6.88
|
+$26.83K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-2.3K
|
$15.04
|
-$34.59K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-1.1K
|
$15.00
|
-$16.50K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-31K
|
$15.11
|
-$462.88K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+3.5K
|
$6.88
|
+$24.08K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO & President
|
|
+3.4K
|
$6.14
|
+$20.93K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO & President
|
|
+6.8K
|
$6.14
|
+$41.85K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+6.3K
|
$6.88
|
+$43.00K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO & President
|
|
+33K
|
$4.59
|
+$151.80K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-17K
|
$25.11
|
-$435.96K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-64K
|
$25.25
|
-$1.62M
|
|
SEC
|
Foley Todd
|
N/A
|
|
-42K
|
$22.15
|
-$933.47K
|
|
SEC
|
Foley Todd
|
N/A
|
|
-128K
|
$23.11
|
-$2.95M
|
|
SEC
|
Foley Todd
|
N/A
|
|
-224K
|
$22.53
|
-$5.05M
|
|
SEC
|
Foley Todd
|
N/A
|
|
-206K
|
$21.56
|
-$4.45M
|
|
SEC
|
Desikan Nithya
|
Chief Commercial Officer
|
|
+15K
|
$6.88
|
+$99.99K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO & President
|
|
-10K
|
$30.09
|
-$309.63K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO & President
|
|
-9.3K
|
$30.06
|
-$279.20K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO and President
|
|
-2.4K
|
$30.04
|
-$73.57K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO and President
|
|
-13K
|
$30.02
|
-$387.86K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO and President
|
|
-3.9K
|
$30.00
|
-$118.02K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+3K
|
$6.88
|
+$20.64K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO and President
|
|
-16K
|
$30.05
|
-$474.16K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO & President
|
|
-10K
|
$30.01
|
-$303.55K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO & President
|
|
-662
|
$30.00
|
-$19.86K
|
|
SEC
|
Van der Ploeg Leonardus H.T.
|
Chief Scientific Officer
|
|
-200
|
$30.00
|
-$6.00K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO and President
|
|
-563
|
$30.00
|
-$16.89K
|
|
SEC
|
Gottesdiener Keith Michael
|
CEO and President
|
|
-17K
|
$30.08
|
-$496.32K
|
|
SEC
|
Van der Ploeg Leonardus H.T.
|
Chief Scientific Officer
|
|
-9.8K
|
$19.90
|
-$195.02K
|
|
SEC
|
Van der Ploeg Leonardus H.T.
|
Chief Scientific Officer
|
|
-12K
|
$18.84
|
-$226.08K
|
|
SEC
|
Smith Hunter C
|
Chief Financial Officer
|
|
+3K
|
$6.88
|
+$20.64K
|
|
SEC
|
Desikan Nithya
|
Chief Commercial Officer
|
|
+15K
|
$6.88
|
+$99.99K
|
|
SEC
|
Foley Todd
|
N/A
|
|
+379K
|
$26.42
|
+$10.00M
|
|
SEC
|
OrbiMed Capital GP V LLC
|
N/A
|
|
-20K
|
$30.43
|
-$595.82K
|
|
SEC
|
OrbiMed Capital GP V LLC
|
N/A
|
|
-132K
|
$30.88
|
-$4.06M
|
|
SEC
|
Gottesdiener Keith Michael
|
C.E.O. and President
|
|
+3K
|
$4.59
|
+$13.77K
|
|
SEC
|
BARRETT M JAMES
|
N/A
|
|
+4.9M
|
$17.00
|
+$82.97M
|
|
SEC
|
BARRIS PETER J
|
N/A
|
|
+4.9M
|
$17.00
|
+$82.97M
|
|
SEC
|
BASKETT FOREST
|
N/A
|
|
+4.9M
|
$17.00
|
+$82.97M
|
|
SEC
|
Deerfield Private Design Fund III, L.P.
|
N/A
|
|
+937K
|
$17.00
|
+$15.93M
|
|
SEC
|
Foley Todd
|
N/A
|
|
+2.7M
|
$17.00
|
+$45.34M
|
|
SEC
|
Ipsen, S.A.
|
N/A
|
|
+234K
|
$17.00
|
+$3.97M
|
|
SEC
|
ISALY SAMUEL D
|
N/A
|
|
+2.9M
|
$17.00
|
+$49.32M
|
|
SEC
|
KERINS PATRICK J
|
N/A
|
|
+4.9M
|
$17.00
|
+$82.97M
|
|
SEC
|
Meeker David P
|
N/A
|
|
+80K
|
$17.00
|
+$1.35M
|
|
SEC
|
MOTT DAVID M
|
N/A
|
|
+4.9M
|
$17.00
|
+$82.97M
|
|
SEC
|
MPM BIOVENTURES V LLC
|
N/A
|
|
+2.7M
|
$17.00
|
+$45.34M
|
|
SEC
|
NEA 13 GP, Ltd
|
N/A
|
|
+4.9M
|
$17.00
|
+$82.97M
|
|
SEC
|
PFIZER INC
|
N/A
|
|
+1.4M
|
$17.00
|
+$24.27M
|
|
SEC
|
SANDELL SCOTT D
|
N/A
|
|
+4.9M
|
$17.00
|
+$82.97M
|
|
SEC
|
Viswanathan Ravi
|
N/A
|
|
+4.9M
|
$17.00
|
+$82.97M
|
|
SEC
|
BAKER JULIAN
|
N/A
|
|
+2M
|
$7.34
|
+$15.04M
|
|