SEC
|
Hirano Patricia C
|
SEE REMARKS
|
|
-3.8K
|
$82.76
|
-$316.97K
|
|
SEC
|
Hirano Patricia C
|
SEE REMARKS
|
|
-266
|
$84.25
|
-$22.41K
|
|
SEC
|
Hirano Patricia C
|
SEE REMARKS
|
|
-3.8K
|
$70.11
|
-$265.16K
|
|
SEC
|
Hirano Patricia C
|
SEE REMARKS
|
|
-156K
|
$68.51
|
-$10.71M
|
|
SEC
|
Pauls Matthew
|
N/A
|
|
-5.9K
|
$71.55
|
-$424.79K
|
|
SEC
|
Anish Bhatnagar
|
CHIEF EXECUTIVE OFFICER
|
|
-699K
|
$67.62
|
-$47.27M
|
|
SEC
|
Huang Michael F.
|
Sr. VP of Clinical Development
|
|
-15K
|
$69.51
|
-$1.01M
|
|
SEC
|
Mackaness James H
|
CHIEF FINANCIAL OFFICER
|
|
-91K
|
$69.44
|
-$6.29M
|
|
SEC
|
Manning Meredith
|
Chief Commercial Officer
|
|
-45K
|
$67.28
|
-$3.04M
|
|
SEC
|
Yen Kristen
|
SEE REMARKS
|
|
-96K
|
$66.77
|
-$6.38M
|
|
SEC
|
Anish Bhatnagar
|
CHIEF EXECUTIVE OFFICER
|
|
-21K
|
$45.78
|
-$965.55K
|
|
SEC
|
Hirano Patricia C
|
SEE REMARKS
|
|
-3K
|
$45.78
|
-$138.71K
|
|
SEC
|
Mackaness James H
|
CHIEF FINANCIAL OFFICER
|
|
-7.9K
|
$45.78
|
-$360.47K
|
|
SEC
|
Yen Kristen
|
SEE REMARKS
|
|
-4.9K
|
$45.78
|
-$222.49K
|
|
SEC
|
Anish Bhatnagar
|
CHIEF EXECUTIVE OFFICER
|
|
-2.5K
|
$48.30
|
-$122.05K
|
|
SEC
|
Hirano Patricia C
|
SEE REMARKS
|
|
-832
|
$48.30
|
-$40.19K
|
|
SEC
|
Yen Kristen
|
SEE REMARKS
|
|
-397
|
$48.30
|
-$19.18K
|
|
SEC
|
Hirano Patricia C
|
See Remarks
|
|
-6.2K
|
$38.29
|
-$239.08K
|
|
SEC
|
Yen Kristen
|
See Remarks
|
|
-38K
|
$37.34
|
-$1.41M
|
|
SEC
|
Anish Bhatnagar
|
Chief Executive Officer
|
|
-93K
|
$35.67
|
-$3.33M
|
|
SEC
|
Mackaness James H
|
Chief Financial Officer
|
|
-32K
|
$36.41
|
-$1.18M
|
|
SEC
|
Anish Bhatnagar
|
Chief Executive Officer
|
|
-28K
|
$28.65
|
-$794.06K
|
|
SEC
|
Hirano Patricia C
|
See Remarks
|
|
-3.8K
|
$28.65
|
-$109.53K
|
|
SEC
|
Mackaness James H
|
Chief Financial Officer
|
|
-4.2K
|
$28.65
|
-$119.93K
|
|
SEC
|
Yen Kristen
|
See Remarks
|
|
-4K
|
$28.65
|
-$113.54K
|
|
SEC
|
Anish Bhatnagar
|
Chief Executive Officer
|
|
-54K
|
$27.49
|
-$1.47M
|
|
SEC
|
Hirano Patricia C
|
See Remarks
|
|
-7.4K
|
$27.49
|
-$202.90K
|
|
SEC
|
Mackaness James H
|
Chief Financial Officer
|
|
-8.1K
|
$27.49
|
-$222.15K
|
|
SEC
|
Yen Kristen
|
See Remarks
|
|
-7.7K
|
$27.49
|
-$210.30K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+867K
|
$17.44
|
+$15.12M
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+143K
|
$5.96
|
+$854.06K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+35K
|
$5.38
|
+$188.30K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+85K
|
$5.29
|
+$449.65K
|
|
SEC
|
EDELMAN JOSEPH
|
N/A
|
|
+80K
|
$5.08
|
+$406.40K
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
-10K
|
$0.91
|
-$9.10K
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
-420K
|
$1.11
|
-$466.28K
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
-181K
|
$2.70
|
-$487.41K
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
+3.8M
|
$0.85
|
+$3.25M
|
|
SEC
|
Harris William G
|
N/A
|
|
+29K
|
$0.09
|
+$2.60K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+56K
|
$0.36
|
+$20.28K
|
|
SEC
|
Volck Birgitte
|
N/A
|
|
+36K
|
$0.36
|
+$12.93K
|
|
SEC
|
Anish Bhatnagar
|
Chief Executive Officer
|
|
-39K
|
$0.37
|
-$14.44K
|
|
SEC
|
Harris William G
|
N/A
|
|
+14K
|
$0.18
|
+$2.48K
|
|
SEC
|
Mackaness James H
|
Chief Financial Officer
|
|
+11K
|
$0.89
|
+$10.00K
|
|
SEC
|
Harris William G
|
N/A
|
|
+11K
|
$0.22
|
+$2.48K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+22K
|
$0.91
|
+$20.00K
|
|
SEC
|
Volck Birgitte
|
N/A
|
|
+14K
|
$0.91
|
+$12.75K
|
|
SEC
|
Harris William G
|
N/A
|
|
+8.5K
|
$0.29
|
+$2.46K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+17K
|
$1.21
|
+$20.00K
|
|
SEC
|
Volck Birgitte
|
N/A
|
|
+11K
|
$1.21
|
+$12.75K
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
-2.1M
|
$1.88
|
-$3.90M
|
|
SEC
|
Harris William G
|
N/A
|
|
+4.8K
|
$0.47
|
+$2.26K
|
|
SEC
|
Anish Bhatnagar
|
Chief Executive Officer
|
|
-36K
|
$2.11
|
-$76.63K
|
|
SEC
|
Hirano Patricia C
|
See Remarks
|
|
-12K
|
$2.11
|
-$25.24K
|
|
SEC
|
Yen Kristen
|
See Remarks
|
|
-5.7K
|
$2.11
|
-$12.02K
|
|
SEC
|
Harris William G
|
N/A
|
|
+5.4K
|
$0.42
|
+$2.27K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+10K
|
$1.74
|
+$17.50K
|
|
SEC
|
Volck Birgitte
|
N/A
|
|
+6.6K
|
$1.74
|
+$11.50K
|
|
SEC
|
COLLINSON STUART J
|
N/A
|
|
+1K
|
$1.72
|
+$1.75K
|
|
SEC
|
Harris William G
|
N/A
|
|
+5.5K
|
$1.72
|
+$9.41K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+10K
|
$1.72
|
+$17.50K
|
|
SEC
|
Volck Birgitte
|
N/A
|
|
+6.7K
|
$1.72
|
+$11.50K
|
|
SEC
|
Abingworth LLP
|
N/A
|
|
+3.3M
|
$1.65
|
+$5.50M
|
|
SEC
|
Mackaness James H
|
Chief Financial Officer
|
|
+6.1K
|
$1.65
|
+$10.00K
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
+7.6M
|
$1.65
|
+$12.50M
|
|
SEC
|
Sinclair Andrew
|
N/A
|
|
+3.3M
|
$1.65
|
+$5.50M
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
+339K
|
$1.97
|
+$667.99K
|
|
SEC
|
ORACLE PARTNERS LP
|
N/A
|
|
-200K
|
$3.39
|
-$678.82K
|
|
SEC
|
COLLINSON STUART J
|
N/A
|
|
+3.6K
|
$3.05
|
+$10.84K
|
|
SEC
|
Harris William G
|
N/A
|
|
+3.1K
|
$3.05
|
+$9.41K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+5.7K
|
$3.05
|
+$17.50K
|
|
SEC
|
Volck Birgitte
|
N/A
|
|
+3.1K
|
$3.05
|
+$9.41K
|
|
SEC
|
Anish Bhatnagar
|
Chief Executive Officer
|
|
+381K
|
$3.35
|
+$1.28M
|
|
SEC
|
Hirano Patricia C
|
See Remarks
|
|
+117K
|
$3.35
|
+$390.28K
|
|
SEC
|
Mackaness James H
|
Chief Financial Officer
|
|
+10K
|
$3.35
|
+$33.50K
|
|
SEC
|
Yen Kristen
|
See Remarks
|
|
+56K
|
$3.35
|
+$185.93K
|
|
SEC
|
COLLINSON STUART J
|
N/A
|
|
+6.9K
|
$3.35
|
+$23.00K
|
|
SEC
|
Harris William G
|
N/A
|
|
+5.6K
|
$3.35
|
+$18.81K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+10K
|
$3.35
|
+$35.00K
|
|
SEC
|
Volck Birgitte
|
N/A
|
|
+5.8K
|
$3.35
|
+$19.52K
|
|
SEC
|
Vivo Ventures V Affiliates Fund, L.P.
|
N/A
|
|
-34K
|
$1.62
|
-$55.13K
|
|
SEC
|
Vivo Ventures V Affiliates Fund, L.P.
|
N/A
|
|
-18K
|
$1.55
|
-$28.01K
|
|
SEC
|
Vivo Ventures V Affiliates Fund, L.P.
|
N/A
|
|
-62K
|
$1.55
|
-$95.59K
|
|
SEC
|
Vivo Ventures V Affiliates Fund, L.P.
|
N/A
|
|
-42K
|
$1.55
|
-$64.52K
|
|
SEC
|
Melincoff Gwen A
|
N/A
|
|
+10K
|
$1.54
|
+$15.40K
|
|
SEC
|
Vivo Ventures V Affiliates Fund, L.P.
|
N/A
|
|
-97K
|
$1.55
|
-$150.39K
|
|
SEC
|
Vivo Ventures V Affiliates Fund, L.P.
|
N/A
|
|
-8.8K
|
$1.55
|
-$13.58K
|
|
SEC
|
Vivo Ventures V Affiliates Fund, L.P.
|
N/A
|
|
-334K
|
$1.57
|
-$525.03K
|
|
SEC
|
Vivo Ventures V Affiliates Fund, L.P.
|
N/A
|
|
-31K
|
$1.59
|
-$48.57K
|
|
SEC
|
Abingworth LLP
|
N/A
|
|
+2.3M
|
$1.20
|
+$2.76M
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
+2.6M
|
$1.20
|
+$3.08M
|
|
SEC
|
Sinclair Andrew
|
N/A
|
|
+2.3M
|
$1.20
|
+$2.76M
|
|
SEC
|
ORACLE PARTNERS LP
|
N/A
|
|
+57K
|
$2.14
|
+$122.13K
|
|
SEC
|
BIOASIA INVESTMENTS IV LLC
|
N/A
|
|
-91K
|
$1.93
|
-$175.10K
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
+836K
|
$2.14
|
+$1.79M
|
|
SEC
|
ORACLE PARTNERS LP
|
N/A
|
|
+130K
|
$1.22
|
+$159.04K
|
|
SEC
|
SCHULER JACK W
|
N/A
|
|
+3M
|
$1.61
|
+$4.88M
|
|
SEC
|
Sinclair Andrew
|
N/A
|
|
+4.7M
|
$1.60
|
+$7.47M
|
|
SEC
|
FEINBERG LARRY N
|
N/A
|
|
+1.2M
|
$1.61
|
+$2.00M
|
|
SEC
|
TECHNOLOGY PARTNERS AFFILIATES VII LP
|
N/A
|
|
+297K
|
$3.31
|
+$983.82K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+9.1K
|
$2.05
|
+$18.63K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+19K
|
$2.03
|
+$39.41K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+1.2K
|
$2.05
|
+$2.46K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+1.8K
|
$2.05
|
+$3.69K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+5.5K
|
$2.05
|
+$11.27K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+30K
|
$1.95
|
+$58.50K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+25K
|
$1.90
|
+$47.50K
|
|
SEC
|
ORACLE PARTNERS LP
|
N/A
|
|
+50K
|
$1.80
|
+$90.00K
|
|
SEC
|
Vivo Ventures Fund V, L.P.
|
N/A
|
|
+326K
|
$3.40
|
+$1.11M
|
|
SEC
|
COLLINSON STUART J
|
N/A
|
|
+3.8K
|
$1.73
|
+$6.60K
|
|
SEC
|
DALAL RAJEN
|
N/A
|
|
+3.8K
|
$1.73
|
+$6.60K
|
|
SEC
|
ENGELSEN STEINAR J
|
N/A
|
|
+8.1K
|
$1.73
|
+$14.03K
|
|
SEC
|
ENGLEMAN EDGAR
|
N/A
|
|
+5.1K
|
$1.73
|
+$8.77K
|
|
SEC
|
Glasheen James Walter
|
N/A
|
|
+4K
|
$1.73
|
+$6.85K
|
|
SEC
|
Harris William G
|
N/A
|
|
+5.4K
|
$1.73
|
+$9.43K
|
|
SEC
|
Kirnon Stephen
|
N/A
|
|
+5.4K
|
$1.73
|
+$9.34K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+8.7K
|
$1.73
|
+$15.03K
|
|
SEC
|
SHAH MAHENDRA
|
N/A
|
|
+3.5K
|
$1.73
|
+$6.00K
|
|
SEC
|
ENGLEMAN EDGAR
|
N/A
|
|
+1.1M
|
$1.84
|
+$2.00M
|
|
SEC
|
Vivo Ventures Fund V, L.P.
|
N/A
|
|
+1.1M
|
$1.84
|
+$2.00M
|
|
SEC
|
COLLINSON STUART J
|
N/A
|
|
+13K
|
$0.52
|
+$6.58K
|
|
SEC
|
DALAL RAJEN
|
N/A
|
|
+13K
|
$0.52
|
+$6.58K
|
|
SEC
|
ENGELSEN STEINAR J
|
N/A
|
|
+27K
|
$0.52
|
+$14.00K
|
|
SEC
|
ENGLEMAN EDGAR
|
N/A
|
|
+17K
|
$0.52
|
+$8.75K
|
|
SEC
|
Glasheen James Walter
|
N/A
|
|
+13K
|
$0.52
|
+$6.84K
|
|
SEC
|
Harris William G
|
N/A
|
|
+18K
|
$0.52
|
+$9.41K
|
|
SEC
|
Kirnon Stephen
|
N/A
|
|
+18K
|
$0.52
|
+$9.32K
|
|
SEC
|
MARIO ERNEST
|
N/A
|
|
+29K
|
$0.52
|
+$15.00K
|
|
SEC
|
SHAH MAHENDRA
|
N/A
|
|
+12K
|
$0.52
|
+$5.99K
|
|
SEC
|
Vivo Ventures V, LLC
|
N/A
|
|
+17K
|
$0.52
|
+$8.75K
|
|